Food-dependent, exercise-induced anaphylaxis (FDEIA) is a rare and potentially life-threatening syndrome, which occurs only during or soon after a vigorous exercise preceded by ingestion of sensitizing food. The exact pathomechanizm of this phenomenon remains unclear. The authors present a brief review of the literature representing current knowledge about this syndrome. In addition, they discuss the results of their experiment which demonstrates for the first time, that a patient who underwent anaphylactic shock after celery ingestion followed by vigorous exercise, exhibited histamine releasability several times greater comparing to controls. The results of this experiment indicate possible importance of individually increased histamine releasability in the pathomechanism of food-dependent exercise-induced anaphylaxis.