An increasing prevalence of allergy during last decades led to increasing interest in effective treatment and prophylaxis. Allergy, due to variety of symptoms, influence on different way on patients’ everyday psychological, mental and social functioning. Symptom scales and validated quality of life questionnaires both should be use to assess treatment effectiveness. Health-related Quality of Life (HQLR) is defined as an individual perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectation, standards and concerns in the context of disease.

In allergic diseases quality of life means a broad ranging concept affected in a complex way by the person’s physical state, psychological state, health outcomes expectations, social relationship. Several studies proved the influence on allergy on perception, emotions, decision making processes. The impact of disease and treatment on disability and daily functioning could be evaluated by using generic or disease specific questionnaires. Visual Analogue Scale for Quality of Life, SF 36, Sickness Impact Profile, Nottingham Health Profile, General Well-Being Scale are most often recommended generic questionnaires in allergic diseases. Several disease-specific questionnaires are available for asthma patients (as Asthma Quality of Life Questionnaire, Living with Asthma Questionnaire), allergic rhinitis (Rhinoconjuctivitis Quality of Life Questionnaire), skin manifestation of allergy Dermatology – specific Quality of Life (DSQL) questionnaire and venom allergy Expectation of outcome’ questionnaire. Quality of life research in children is based mainly on generic questionnaires such Children’s Health Questionnaire. Specific questionnaire is available in asthma.