Nebulisation represents the oldest aerosol therapy technique. Its origins may even be traced among shamanic or folk medicine of Ancient cultures. Aerosol therapy has undergone extensive improvements in recent decades. The introduction of pressure inhalers for single pMDI dosages did revolutionize the treatment of respiratory system diseases which require the application of drugs restoring bronchospasm. Powder inhalers constituted another step in the improvement of inhalants’ administration. The same technologies, facilitating the application of medicines in an aerosol form, have constraints which do not occur in case of nebulisation and which may be the reason for the absence of desired  clinical effects. Owing to the rapid  technological development, the introduction of new devices, pharmaceuticals (or extending the indications for already registered drugs), as well as the results of clinical research, it becomes indispensable to take a new look at the problem of nebulisation.